Quick estimate
Cost and timeline,
with and without
a hybrid arm.
Set your phase and therapeutic area to see how a hybrid control arm changes recruited patients, duration, and control cost. Open the assumptions to see the math. These figures are illustrative, not a quote.
01The model
A traditional RCT, next to a hybrid arm.
A hybrid control arm reduces and strengthens the control arm by replacing a share of recruited controls with external ones. It does not fully replace the placebo arm, which regulators still generally require.
Trial phase
Therapeutic area
Note-derived subjective scales. Our first wedge.
Full control arm · all recruitedRecruited
External control · built from records
Built from real-world records. Item-level traceable.Illustrative
Traditional RCT
Control patients to recruit180
Recruitment duration14 mo
Estimated control cost$9.4M
Hybrid with Sapien
Control patients to recruit90
Recruitment duration10 mo
Estimated control cost$5.3M
~44%lower control cost
4 mofaster recruitment
90controls replaced with data
Illustrative, not a quote. Actual figures depend on your protocol, indication, and available real-world data.
Model your own program →Turn an estimate into
a feasibility map.
Bring your protocol. We map it against available real-world data and show the path a hybrid control arm opens toward approval.